Pharmacological enhancement of fibrinolysis.
نویسندگان
چکیده
منابع مشابه
Pharmacological Fibrinolysis
Until fairly recently, arteriosclerosis and its complications were philosophically accepted as an inevitable consequence of ageing; but the steady increase of coronary deaths in particular, and the equally steady decrease ^ the age of onset have put an end to such laissez-faire complacency. To Pinpoint the epidemic acceleration of coronary deaths, a senior colleague told me that when he took th...
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Systemic administration of tissue plasminogen activator (tPA) remains the fastest way to initiate treatment for acute ischemic stroke. The presence of a proximal arterial occlusion should not be viewed as an insurmountable predictor of tPA failure. Because tPA works by induction of partial recanalization of large thrombi, early augmentation of fibrinolysis to improve recanalization is desirable...
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BACKGROUND Ultrasound at frequencies of 0.5 to 1 MHz and intensities of > or =0.5 W/cm2 accelerates enzymatic fibrinolysis in vitro and in some animal models, but unacceptable tissue heating can occur, and limited penetration would restrict application to superficial vessels. Tissue heating is less and penetration better at lower frequencies, but little information is available regarding the ef...
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The effect of ultrasound on the rate of fibrinolysis has been investigated using an in vitro system. Plasma or blood clots containing a trace label of 125I fibrin were suspended in plasma containing plasminogen activator and intermittently exposed to continuous wave 1-MHz ultrasound at intensities up to 8 W/cm2. Plasma clot lysis at 1 h with 1 microgram/ml recombinant tissue plasminogen activat...
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Pharmacologic reperfusion of patients with acute ST segment elevation myocardial infarction is designed to achieve prompt high-quality reperfusion, prevent recurrent ischemia and reinfarction, maintain long-term patency, and to enhance patient survival and quality of life. Because monotherapy with fibrinolytics is by itself unable to achieve all of these objectives, antithrombotic, anti-platele...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1969
ISSN: 0021-9746
DOI: 10.1136/jcp.22.3.368-b